Cubs vs. White Sox Prediction: Cubs Predicted to Win Friday's MLB Matchup [7/25/2025]

The Chicago White Sox and Chicago Cubs will meet in MLB action at Rate Field on Friday, starting at 7:40PM ET.

Adrian Houser (5-2, 1.89 ERA) will be on the bump for the White Sox, up against Shota Imanaga (7-3, 2.40 ERA) for the Cubs.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Cubs vs. White Sox predictions page.

White Sox vs. Cubs Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Friday's MLB game between the Cubs and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 64% chance of beating the White Sox.

According to our model, the bookmakers have got it right, and the Cubs and White Sox each have a 50% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of going over.

Cubs vs. White Sox Odds [7/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	White Sox
Run Line	-1.5 (-111)	+1.5 (-105)
Moneyline	-185	+156
Total	o8 (-110)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Cubs vs. White Sox matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Cubs vs. White Sox Game-Day Updates and Essential Details

Friday's MLB action between the White Sox and Cubs at Rate Field is scheduled to begin at 7:40PM ET.

• Who: Chicago Cubs vs. Chicago White Sox
• Date: Friday, July 25, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Friday's Cubs vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 64% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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