Chicago Bears vs. Detroit Lions early prediction: Expert picks for NFL Week 2, 2025

The Chicago Bears and Detroit Lions will meet in Week 2 of the NFL season at Ford Field on Sunday, September 14, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bears vs. Lions predictions page.

Chicago vs. Detroit early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bears vs. Lions game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bears 33%, Lions 67%
• Predicted final score: Bears 21-26 Lions
• Spread: Bears (+4.5) 46%, Lions (-4.5) 54%
• Total points (48.5): Over 50%, Under 50%

As of September 7, 2025, these Bears-Lions figures and predictions reflect the latest data and insights available.

Bears vs. Lions Week 2 details

The NFL Week 2 game between the Lions and Bears at Ford Field is scheduled for September 14, 2025.

• Who: Chicago Bears vs. Detroit Lions
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Ford Field

Bears vs. Lions opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Bears +4.5 (-105), Lions -4.5 (-115)
• Moneyline: Bears +190, Lions -230
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Lions, with a 67% win probability, will likely beat the Bears in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bears vs. Lions matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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