Charleston Southern vs. William & Mary prediction: Why William & Mary is favored to win in college football Week 4, 2025

William & Mary will take on Charleston Southern in Week 4 college football action at Walter J. Zable Stadium at Cary Field on Saturday, starting at 4:00PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts William & Mary as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Charleston Southern vs. William & Mary predictions page.

Charleston Southern vs. William & Mary prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Charleston Southern vs. William & Mary 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives William & Mary an 81% chance of defeating Charleston Southern. Our predicted final score has William & Mary winning 29-17.

According to our model, Charleston Southern (+12.5) has a 52% chance of covering the spread, while the 46.5-point over/under has a 54% chance of staying under.

Charleston Southern vs. William & Mary odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Charleston Southern	William & Mary
Spread	+12.5 (-110)	-12.5 (-110)
Moneyline	+340	-410
Total	o46.5 (-110)	u46.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Charleston Southern vs. William & Mary picks and best bets

Our model's strongest edge in today's Charleston Southern vs. William & Mary matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Charleston Southern vs. William & Mary game-day updates and essential details

Saturday's college football matchup between William & Mary and Charleston Southern at Walter J. Zable Stadium at Cary Field is scheduled to start at 4:00PM ET.

• Who: Charleston Southern vs. William & Mary
• Date: Saturday, September 20, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Walter J. Zable Stadium at Cary Field

Dimers' in-depth preview of Saturday's Charleston Southern vs. William & Mary matchup includes our prediction, picks and the latest betting odds.

Before making any Charleston Southern vs. William & Mary picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict William & Mary, with an 81% win probability, will likely beat Charleston Southern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Charleston Southern vs. William & Mary insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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