Charleston Southern vs. Vanderbilt prediction: Vanderbilt favored to win in college football Week 1, 2025

Vanderbilt will face Charleston Southern in college football action at FirstBank Stadium on Saturday, starting at 7:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Vanderbilt as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Charleston Southern vs. Vanderbilt predictions page.

Charleston Southern vs. Vanderbilt prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Charleston Southern vs. Vanderbilt 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Vanderbilt a 100% chance of defeating Charleston Southern. Our predicted final score has Vanderbilt winning 42-5.

According to our model, Charleston Southern (+38.5) has a 51% chance of covering the spread, while the over/under total of 50.5 points has a 52% chance of going over.

Charleston Southern vs. Vanderbilt odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Charleston Southern	Vanderbilt
Spread	+38.5 (-120)	-38.5 (+100)
Moneyline	+8000	-100000
Total	o50.5 (-108)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Charleston Southern vs. Vanderbilt picks and best bets

Our model's strongest edge in today's Charleston Southern vs. Vanderbilt matchup is on the spread.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Charleston Southern vs. Vanderbilt game-day updates and essential details

Saturday's college football game between Vanderbilt and Charleston Southern at FirstBank Stadium is scheduled to commence at 7:00PM ET.

• Who: Charleston Southern vs. Vanderbilt
• Date: Saturday, August 30, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: FirstBank Stadium

Dimers.com's full preview of Saturday's Charleston Southern vs. Vanderbilt matchup includes our prediction, picks and the latest betting odds.

Before making any Charleston Southern vs. Vanderbilt picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Vanderbilt, with a 100% win probability, will likely beat Charleston Southern on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Charleston Southern vs. Vanderbilt insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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