Chargers vs. 49ers Week 10 Prediction and Odds - Nov 13, 2022

The San Francisco 49ers and Los Angeles Chargers meet in Week 10 of the NFL season at Levi's Stadium on Sunday, with kickoff at 8:20PM ET.

Dimers' free betting picks for Chargers vs. 49ers, as well as game predictions, betting odds and projected player stats, are featured in this article.

Who will win Chargers vs. 49ers?

Based on trusted machine learning and data, Dimers.com has simulated Sunday's Chargers-49ers NFL matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the 49ers a 78% chance of defeating the Chargers in Week 10 of the NFL season.

More: Chargers vs. 49ers Simulated 10K Times

Chargers vs. 49ers Week 10 Odds

• Spread: 49ers -8 (-105), Chargers +8 (-107)
• Moneyline: 49ers -325, Chargers +300
• Total: Over/Under 45.5 (-110/-105)

Point Spread, Moneyline and Over/Under

The 49ers are -8 favorites versus the Chargers, with -105 at BetMGM the best odds currently available.

For the underdog Chargers (+8) to cover the spread, PointsBet has the best odds currently on the market at -107.

DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -325. That means you can risk $325 to win $100, for a total payout of $425, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Chargers at +300, where you can bet $100 to profit $300, earning a total payout of $400, if they win.

The Over/Under for total points scored sits at 45.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the bookmakers have got it right and both the Chargers and 49ers are a 50% chance of covering the spread, while the Over/Under total of 45.5 points is also considered an equal 50-50 chance of hitting.

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Best Bets for Chargers vs. 49ers

• Spread: 49ers -8 @ -105 via BetMGM (50% probability)
• Moneyline: 49ers @ -325 via DraftKings Sportsbook (78% probability)
• Total: Under 45.5 @ -105 via PointsBet (50% probability)

Dimers' best bets are based on detailed modeling and betting expertise to bring you the best possible plays 24/7.

Chargers vs. 49ers Prediction

Dimers.com's predicted final score for LA Chargers vs. San Francisco at Levi's Stadium in Week 10 has the 49ers winning 26-18.

Click or tap on See Matchup for more.

Dimers has full coverage of this week's Chargers-49ers matchup in Week 10, including pregame predictions, free picks, and live updates.

Chargers vs. 49ers Player Props

Who will score the first touchdown in Chargers vs. 49ers? The latest data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Chargers and 49ers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop bets for Sunday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in Chargers vs. 49ers.

DimersBOT gives McCaffrey a 16.6% chance of scoring the first TD at Levi's Stadium, while the 49ers RB is a 61.2% chance of scoring an anytime touchdown.

Scroll down for our full list of first and anytime TD scorer probabilities.

First Touchdown Scorer Probabilities

Los Angeles Chargers

• Austin Ekeler: 12.9% probability
• Joshua Palmer: 6.9% probability
• Gerald Everett: 5.7% probability
• DeAndre Carter: 5.3% probability
• Justin Herbert: 3.8% probability

San Francisco 49ers

• Christian McCaffrey: 16.6% probability
• Deebo Samuel: 8.1% probability
• George Kittle: 6.4% probability
• Brandon Aiyuk: 6.1% probability
• Jimmy Garoppolo: 4.4% probability

Anytime Touchdown Scorer Probabilities

Los Angeles Chargers

• Austin Ekeler: 53.7% probability
• Joshua Palmer: 31.9% probability
• Gerald Everett: 26.3% probability
• DeAndre Carter: 26.1% probability
• Justin Herbert: 18.1% probability

San Francisco 49ers

• Christian McCaffrey: 61.2% probability
• Deebo Samuel: 35.0% probability
• George Kittle: 29.9% probability
• Brandon Aiyuk: 28.1% probability
• Jimmy Garoppolo: 20.7% probability

Chargers-49ers Projected Player Stats

Of the starting quarterbacks, the Chargers' Justin Herbert is projected for 255 passing yards. The 49ers' Jimmy Garoppolo is expected to throw for a whopping 271 yards.

Chargers Starting QB

• Justin Herbert: 255 projected yards

49ers Starting QB

• Jimmy Garoppolo: 271 projected yards

Chargers Rushing

• Austin Ekeler: 52 projected yards
• Isaiah Spiller: 18 projected yards
• Justin Herbert: 12 projected yards

49ers Rushing

• Christian McCaffrey: 70 projected yards
• Elijah Mitchell: 21 projected yards
• Deebo Samuel: 21 projected yards

Chargers Receiving

• Joshua Palmer: 66 projected yards
• Gerald Everett: 50 projected yards
• Austin Ekeler: 46 projected yards
• DeAndre Carter: 41 projected yards
• Michael Bandy: 38 projected yards

49ers Receiving

• George Kittle: 61 projected yards
• Deebo Samuel: 50 projected yards
• Brandon Aiyuk: 42 projected yards
• Christian McCaffrey: 39 projected yards
• Jauan Jennings: 21 projected yards

Don't forget, DimersBOT updates frequently, so check this page for any changes to our betting analysis before Chargers vs. 49ers on Sunday November 13, 2022.

Chargers vs. 49ers 2022

The NFL Week 10 matchup between the 49ers and Chargers at Levi's Stadium is scheduled to start at 8:20PM ET.

• Who: Los Angeles Chargers vs. San Francisco 49ers
• Date: Sunday November 13, 2022
• Time: 8:20PM ET / 5:20PM PT
• Venue: Levi's Stadium

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Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!