Panthers vs. Patriots prediction: New England favored to win in NFL Week 4, 2025

The New England Patriots and Carolina Panthers are scheduled to meet in Week 4 of the NFL season at Gillette Stadium on Sunday, starting at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the Patriots as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Panthers-Patriots game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Patriots with a win probability of 70%, while the Panthers have 30%."

This gameday Panthers vs. Patriots betting preview builds on my Panthers vs. Patriots prediction that was posted earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Panthers vs. Patriots predictions page.

Panthers vs. Patriots Predictions

Since our Panthers-Patriots predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Panthers and Patriots 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Patriots a 70% chance of beating the Panthers in Week 4 of the NFL season. Our predicted final score has the Patriots winning 24-19.

According to our model, the bookmakers have got it right, and the Panthers and Patriots each have a 50% chance of covering the spread, while the 42.5-point over/under has a 54% chance of going over.

Panthers vs. Patriots odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Panthers	Patriots
Spread	+5.5 (-108)	-5.5 (-110)
Moneyline	+220	-250
Total	o42.5 (-110)	u42.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Panthers vs. Patriots picks and best bets

Our model's strongest edge in today's Panthers vs. Patriots matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Panthers vs. Patriots TD scorers

Who will score an anytime touchdown in Panthers vs. Patriots?

According to our model, Carolina's Chuba Hubbard is most likely to score the first touchdown in Panthers vs. Patriots.

Our projections give Hubbard a 9.9% chance of scoring the first TD at Gillette Stadium, while the Panthers running back is a 40.3% chance of registering an anytime touchdown.

First touchdown scorer predictions

Carolina Panthers

Player	First TD Probability
Chuba Hubbard (RB)	9.9%
Tetairoa McMillan (WR)	7.7%
Rico Dowdle (RB)	5.0%

New England Patriots

Player	First TD Probability
Rhamondre Stevenson (RB)	8.2%
TreVeyon Henderson (RB)	8.1%
Hunter Henry (TE)	6.8%

Anytime touchdown scorer predictions

Carolina Panthers

Player	Anytime TD Probability
Chuba Hubbard (RB)	40.3%
Tetairoa McMillan (WR)	33.0%
Rico Dowdle (RB)	23.0%

New England Patriots

Player	Anytime TD Probability
Rhamondre Stevenson (RB)	33.2%
TreVeyon Henderson (RB)	32.8%
Hunter Henry (TE)	28.2%

Panthers vs Patriots player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and Patriots. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Panthers-Patriots page now to access every player prop projection.

Panthers vs. Patriots quarterbacks

Of the starting quarterbacks, the Panthers' Bryce Young is projected to throw for fewer yards than the Patriots' Drake Maye.

Panthers rushing

Chuba Hubbard, Rico Dowdle and Bryce Young are projected to be the leading rushers for the Panthers.

Player	Position
Chuba Hubbard	RB
Rico Dowdle	RB
Bryce Young	QB

Patriots rushing

TreVeyon Henderson, Rhamondre Stevenson and Drake Maye are expected to lead the Patriots in rushing yards.

Player	Position
TreVeyon Henderson	RB
Rhamondre Stevenson	RB
Drake Maye	QB

Panthers receiving

Tetairoa McMillan, Hunter Renfrow, Tommy Tremble, David Moore and Brycen Tremayne are projected to top the receiving yards for the Panthers.

Player	Position
Tetairoa McMillan	WR
Hunter Renfrow	WR
Tommy Tremble	TE
David Moore	WR
Brycen Tremayne	WR

Patriots receiving

Hunter Henry, Stefon Diggs, Kayshon Boutte, Mack Hollins and DeMario Douglas are projected to lead the Patriots in receiving yards.

Player	Position
Hunter Henry	TE
Stefon Diggs	WR
Kayshon Boutte	WR
Mack Hollins	WR
DeMario Douglas	WR

Panthers vs. Patriots game-day updates and essential details

The NFL Week 4 action between the Patriots and Panthers at Gillette Stadium is scheduled to begin at 1:00PM ET.

• Who: Carolina Panthers vs. New England Patriots
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

Dimers' in-depth preview of this week's Panthers vs. Patriots matchup includes our prediction, picks and the latest betting odds.

Before making any Panthers vs. Patriots picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Patriots, with a 70% win probability, will likely beat the Panthers in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Patriots insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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