Carolina Panthers vs. New England Patriots early prediction: Expert picks for NFL Week 4, 2025

The Carolina Panthers and New England Patriots will meet in Week 4 of the NFL season at Gillette Stadium on Sunday, September 28, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Patriots as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Panthers vs. Patriots predictions page.

Carolina vs. New England early predictions

Leveraging trusted machine learning and analysis, we have simulated the Panthers vs. Patriots game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Panthers 40%, Patriots 60%
• Predicted final score: Panthers 21-24 Patriots
• Spread: Panthers (+3.5) 59%, Patriots (-3.5) 41%
• Total points (45.5): Over 50%, Under 50%

As of September 21, 2025, these Panthers-Patriots figures and predictions reflect the latest data and insights available.

Panthers vs. Patriots Week 4 details

The NFL Week 4 game between the Patriots and Panthers at Gillette Stadium is scheduled for September 28, 2025.

• Who: Carolina Panthers vs. New England Patriots
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

Panthers vs. Patriots opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Panthers +3.5 (-105), Patriots -3.5 (-115)
• Moneyline: Panthers +154, Patriots -185
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Patriots, with a 60% win probability, will likely beat the Panthers in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. Patriots game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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