Panthers vs. Jaguars prediction: Jacksonville favored to win in NFL Week 1, 2025

The Jacksonville Jaguars will square off with the Carolina Panthers in NFL Week 1 action at EverBank Stadium on Sunday, commencing at 1:00PM ET.

Based on updated simulation results, Dimers' advanced NFL model projects the Jaguars as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Panthers-Jaguars game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Jaguars with a win probability of 65%, while the Panthers have 35%."

This updated Panthers vs. Jaguars betting preview builds on my Panthers vs. Jaguars prediction that was published earlier in the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Panthers vs. Jaguars predictions page.

Panthers vs. Jaguars Predictions

Since our Panthers-Jaguars predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Panthers and Jaguars 10,000 times as part of our NFL predictions coverage.

Our leading predictive model currently gives the Jaguars a 65% chance of defeating the Panthers in Week 1 of the NFL season. Our predicted final score has the Jaguars winning 24-20.

According to our model, the Panthers (+4.5) have a 54% chance of covering the spread, while the 45.5-point over/under has an equal 50-50 chance of hitting.

Panthers vs. Jaguars odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Panthers	Jaguars
Spread	+4.5 (-105)	-4.5 (-105)
Moneyline	+185	-218
Total	o45.5 (-105)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Panthers vs. Jaguars picks and best bets

Our model's biggest edge in today's Panthers vs. Jaguars matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season, with today's best NFL bets populating now.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Panthers vs. Jaguars TD scorers

Who will score the first touchdown in Panthers vs. Jaguars?

According to our list of touchdown scorer predictions for Week 1, Carolina's Chuba Hubbard is most likely to score the first touchdown in Panthers vs. Jaguars.

Our projections give Hubbard an 11.9% chance of scoring the first TD at EverBank Stadium, while the Panthers running back is a 48.1% chance of registering an anytime touchdown.

First touchdown scorer predictions

Carolina Panthers

Player	First TD Probability
Chuba Hubbard (RB)	11.9%
Tetairoa McMillan (WR)	7.1%
Xavier Legette (WR)	5.1%

Jacksonville Jaguars

Player	First TD Probability
Brian Thomas (WR)	10.6%
Tank Bigsby (RB)	9.1%
Travis Etienne (RB)	7.6%

Anytime touchdown scorer predictions

Carolina Panthers

Player	Anytime TD Probability
Chuba Hubbard (RB)	48.1%
Tetairoa McMillan (WR)	32.1%
Xavier Legette (WR)	24.2%

Jacksonville Jaguars

Player	Anytime TD Probability
Brian Thomas (WR)	40.1%
Tank Bigsby (RB)	35.7%
Travis Etienne (RB)	30.7%

For a complete analysis of the most likely first and anytime TD scorers this week, see our NFL Week 1 touchdown scorer predictions

Panthers vs Jaguars player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and Jaguars. For more, check out today's highest-probability NFL prop bets.

Already a Dimers Pro member? Head to our Panthers-Jaguars page now to access every player prop projection.

Panthers vs. Jaguars quarterbacks

Of the starting quarterbacks, the Panthers' Bryce Young is projected to throw for fewer yards than the Jaguars' Trevor Lawrence.

Panthers rushing

Chuba Hubbard, Rico Dowdle and Bryce Young are projected to be the leading rushers for the Panthers.

Player	Position
Chuba Hubbard	RB
Rico Dowdle	RB
Bryce Young	QB

Jaguars rushing

Tank Bigsby, Travis Etienne and Trevor Lawrence are expected to lead the Jaguars in rushing yards.

Player	Position
Tank Bigsby	RB
Travis Etienne	RB
Trevor Lawrence	QB

Panthers receiving

Tetairoa McMillan, Xavier Legette, Ja'Tavion Sanders, Hunter Renfrow and Tommy Tremble are projected to top the receiving yards for the Panthers.

Player	Position
Tetairoa McMillan	WR
Xavier Legette	WR
Ja'Tavion Sanders	TE
Hunter Renfrow	WR
Tommy Tremble	TE

Jaguars receiving

Brian Thomas, Travis Hunter, Brenton Strange, Dyami Brown and Parker Washington are projected to lead the Jaguars in receiving yards.

Player	Position
Brian Thomas	WR
Travis Hunter	WR
Brenton Strange	TE
Dyami Brown	WR
Parker Washington	WR

Panthers vs. Jaguars game-day updates and essential details

The NFL Week 1 action between the Jaguars and Panthers at EverBank Stadium is scheduled to commence at 1:00PM ET.

• Who: Carolina Panthers vs. Jacksonville Jaguars
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: EverBank Stadium

Dimers.com's in-depth preview of this week's Panthers vs. Jaguars matchup includes our prediction, picks and the latest betting odds.

Before making any Panthers vs. Jaguars picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Jaguars, with a 65% win probability, will likely beat the Panthers in Week 1 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Jaguars insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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