Carolina Panthers vs. Jacksonville Jaguars early prediction: Expert picks for NFL Week 1, 2025

The Carolina Panthers and Jacksonville Jaguars will meet in Week 1 of the NFL season at EverBank Stadium on Sunday, September 7, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Jaguars as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Panthers vs. Jaguars predictions page.

Carolina vs. Jacksonville early predictions

Leveraging trusted machine learning and analysis, we have simulated the Panthers vs. Jaguars game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Panthers 42%, Jaguars 58%
• Predicted final score: Panthers 21-23 Jaguars
• Spread: Panthers (+3) 58%, Jaguars (-3) 42%
• Total points (46.5): Over 47%, Under 53%

As of August 31, 2025, these Panthers-Jaguars calculations and predictions reflect the latest data and insights available.

Panthers vs. Jaguars Week 1 details

The NFL Week 1 game between the Jaguars and Panthers at EverBank Stadium is scheduled for September 7, 2025.

• Who: Carolina Panthers vs. Jacksonville Jaguars
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: EverBank Stadium

Panthers vs. Jaguars opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Panthers +3 (-110), Jaguars -3 (-110)
• Moneyline: Panthers +136, Jaguars -158
• Total: Over/Under 46.5 (-110/-104)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Jaguars, with a 58% win probability, will likely beat the Panthers in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. Jaguars game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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