Carolina Panthers vs. Arizona Cardinals updated prediction featuring Chuba Hubbard, James Conner [Week 2, 2025]

Dimers' latest NFL predictions are live for Arizona Cardinals and Carolina Panthers in Week 2, with our model giving the Cardinals a 73% of winning against the Panthers on Sunday.

This update builds on our early Cardinals-Panthers predictions, presenting renewed win probabilities, score projections, and TD predictions for Chuba Hubbard, James Conner, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Panthers vs. Cardinals page.

What's changed? Carolina vs. Arizona updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Panthers vs. Cardinals matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Panthers 27%, Cardinals 73%
• Predicted Final Score: Panthers 18-24 Cardinals
• Spread: Panthers (+6.5) 50%, Cardinals (-6.5) 50%
• Total Points (43.5): Over 50%, Under 50%

As of September 11, 2025, these Panthers-Cardinals figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Panthers-Cardinals on Sunday:

Carolina Panthers

• Chuba Hubbard: 50.0% probability
• Tetairoa McMillan: 32.1% probability
• Xavier Legette: 23.2% probability

Arizona Cardinals

• James Conner: 51.4% probability
• Marvin Harrison: 36.5% probability
• Trey McBride: 31.2% probability

Panthers vs. Cardinals latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Panthers +6.5 (-105), Cardinals -6.5 (-112)
• Moneyline: Panthers +250, Cardinals -298
• Total: Over/Under 43.5 (-110/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Panthers vs. Cardinals Week 2 details

The NFL Week 2 action between the Cardinals and Panthers at State Farm Stadium is scheduled for September 14, 2025.

• Who: Carolina Panthers vs. Arizona Cardinals
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the Cardinals, with a 73% win probability, will likely beat the Panthers in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. Cardinals game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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