Panthers vs. Cardinals prediction: Why Arizona is favored to win in NFL Week 2, 2025

The Arizona Cardinals and Carolina Panthers are scheduled to meet in Week 2 of the NFL season at State Farm Stadium on Sunday, with kickoff at 4:05PM ET.

Based on updated simulations, Dimers' advanced NFL model predicts the Cardinals as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Panthers-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Cardinals with a win probability of 74%, while the Panthers have 26%."

This gameday Panthers vs. Cardinals betting preview builds on my Panthers vs. Cardinals prediction that was posted earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Panthers vs. Cardinals predictions page.

Panthers vs. Cardinals Predictions

Since our Panthers-Cardinals predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Panthers and Cardinals 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Cardinals a 74% chance of defeating the Panthers in Week 2 of the NFL season. Our predicted final score has the Cardinals winning 25-18.

According to our model, the Panthers (+7) have a 54% chance of covering the spread, while the over/under total of 45.5 points has a 53% chance of staying under.

Panthers vs. Cardinals odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	Panthers	Cardinals
Spread	+7 (-110)	-7 (-110)
Moneyline	+275	-310
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

Boost your NFL betting by exploring the latest NFL betting promos, sourced from top sportsbooks and DFS operators.

Panthers vs. Cardinals picks and best bets

Our model's strongest edge in today's Panthers vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Panthers vs. Cardinals TD scorers

Who will score an anytime touchdown in Panthers vs. Cardinals?

According to our model, Arizona's James Conner is most likely to score the first TD in Panthers vs. Cardinals.

Our projections give Conner a 15.6% chance of scoring the first TD at State Farm Stadium, while the Cardinals running back is a 51.5% chance of scoring an anytime touchdown.

First touchdown scorer predictions

Carolina Panthers

Player	First TD Probability
Chuba Hubbard (RB)	11.9%
Tetairoa McMillan (WR)	6.5%
Xavier Legette (WR)	4.3%

Arizona Cardinals

Player	First TD Probability
James Conner (RB)	15.6%
Marvin Harrison (WR)	9.6%
Trey McBride (TE)	8.1%

Anytime touchdown scorer predictions

Carolina Panthers

Player	Anytime TD Probability
Chuba Hubbard (RB)	49.3%
Tetairoa McMillan (WR)	31.1%
Xavier Legette (WR)	21.9%

Arizona Cardinals

Player	Anytime TD Probability
James Conner (RB)	51.5%
Marvin Harrison (WR)	36.1%
Trey McBride (TE)	31.3%

Panthers vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and Cardinals. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Panthers-Cardinals page now to access every player prop projection.

Panthers vs. Cardinals quarterbacks

Of the starting quarterbacks, the Panthers' Bryce Young is projected to throw for fewer yards than the Cardinals' Kyler Murray.

Panthers rushing

Chuba Hubbard, Bryce Young and Rico Dowdle are projected to be the leading rushers for the Panthers.

Player	Position
Chuba Hubbard	RB
Bryce Young	QB
Rico Dowdle	RB

Cardinals rushing

James Conner, Trey Benson and Kyler Murray are expected to lead the Cardinals in rushing yards.

Player	Position
James Conner	RB
Trey Benson	RB
Kyler Murray	QB

Panthers receiving

Tetairoa McMillan, Xavier Legette, Hunter Renfrow, Ja'Tavion Sanders and Chuba Hubbard are projected to top the receiving yards for the Panthers.

Player	Position
Tetairoa McMillan	WR
Xavier Legette	WR
Hunter Renfrow	WR
Ja'Tavion Sanders	TE
Chuba Hubbard	RB

Cardinals receiving

Trey McBride, Marvin Harrison, Michael Wilson, James Conner and Elijah Higgins are projected to lead the Cardinals in receiving yards.

Player	Position
Trey McBride	TE
Marvin Harrison	WR
Michael Wilson	WR
James Conner	RB
Elijah Higgins	TE

Panthers vs. Cardinals game-day updates and essential details

The NFL Week 2 game between the Cardinals and Panthers at State Farm Stadium is scheduled to start at 4:05PM ET.

• Who: Carolina Panthers vs. Arizona Cardinals
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Dimers' comprehensive preview of this week's Panthers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Panthers vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

NFL Week 2 betting promos and codes

Make the most of Dimers' Panthers vs. Cardinals predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Sports betting deal available for Maryland sports fans

To make the most of Sunday's mammoth day of sports, headlined by NFL Sunday action, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $300 in bonus bets from a $5 bet — win or lose.

Plus, find out all the details on the Bet365 Kansas offer which provides a great option for those in the The Sunflower State. Don't miss out!

Conclusion

We predict the Cardinals, with a 74% win probability, will likely beat the Panthers in Week 2 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Stay informed with the latest NFL betting news and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the latest probabilities for the Super Bowl, AFC, NFC and each division.