Cardinals vs. 49ers Predictions and Odds - Nov 7, 2021

The San Francisco 49ers and Arizona Cardinals meet in Week 9 of the NFL season at Levi's Stadium on Sunday, starting at 4:25 PM EST.

Dimers' free betting picks for Cardinals vs. 49ers, as well as our score prediction and best odds, are detailed below.

Who will win Cardinals vs. 49ers?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Sunday's Cardinals-49ers matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the 49ers a 55% chance of beating the Cardinals.

MORE: Full betting guide for Cardinals vs. 49ers

Cardinals vs. 49ers Point Spread, Moneyline and Over/Under

The 49ers are listed as +1 underdogs at home to the Cardinals, with -107 at PointsBet the best odds available.

For the favored Cardinals (-1) to cover the spread, PointsBet also has the best odds on offer at -107.

In a sign of how close this game is expected to be, both the 49ers and Cardinals are at minus-money betting odds to win the game.

BetMGM has the best moneyline odds for the 49ers at -125, which means you can risk $125 to win $100, for a total payout of $225, if they get the W.

Elsewhere, PointsBet has the best moneyline odds for the Cardinals at -120, where you can risk $120 to win $100, for a total payout of $220, if they come out on top.

The Over/Under is set at 45.5 with PointsBet, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -110.

As always, make sure you check all the sportsbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Cardinals (-1) are a 62% chance of covering the spread, while the Over/Under total of 45.5 points is a 55% chance of going Under.

Best Bets for Cardinals vs. 49ers

• Spread: Cardinals -1 at -107 with PointsBet (62% probability) 🔥
• Moneyline: Cardinals Win at -120 with PointsBet (6.8% edge) 🔥
• Over/Under: Under 45.5 at -110 with FanDuel Sportsbook (55% probability)

Every time you see a 🔥, you know it's one of Dimers' best bets today across all sports.

While the 49ers are more likely to win the game, according to DimersBOT, taking the Cardinals moneyline is the best option because of the 6.8% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen here at Dimers.com is crucial to being a profitable bettor in the long run.

MORE: Live scores and win probabilities for all major sports

Cardinals vs. 49ers Predicted Score

Dimers.com's predicted score for Arizona vs. San Francisco at Levi's Stadium this Sunday has the 49ers winning 23-21.

Dimers has full betting coverage of this week's Cardinals-49ers game, including pre-game predictions, free betting picks, live win probabilities, and play-by-play updates.

Don't forget, DimersBOT updates regularly, so check this page for the latest before Cardinals vs. 49ers on Sunday November 7, 2021.

Cardinals vs. 49ers 2021 Game Info

When do the 49ers play the Cardinals?

• Date: Sunday November 7, 2021
• Time: 4:25 PM EST / 1:25 PM PST
• Venue: Levi's Stadium

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