Penrith Panthers vs. Canberra Raiders prediction: Why Panthers are favored to win Friday's NRL Round 25 matchup [8/22/2025]

The Penrith Panthers and Canberra Raiders will lock horns in the National Rugby League (NRL) at Panthers Stadium on Friday, starting at 4:00AM ET.

Based on updated simulations, Dimers' advanced NRL model predicts the Panthers as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Raiders vs. Panthers predictions page.

Panthers vs. Raiders prediction: Who will win Round 25 game?

Using powerful machine learning and data, we have simulated the outcome of Friday's NRL matchup between the Raiders and Panthers 10,000 times as part of our NRL predictions coverage.

Our leading predictive model gives the Panthers a 69% chance of beating the Raiders.

According to our model, the Panthers (-3.5) have a 60% chance of covering the spread, while the over/under total of 40.5 has a 58% chance of going over.

Raiders vs. Panthers odds

We have researched the best NRL odds in America for this game, which are listed here:

Bet Type	Raiders	Panthers
H2H (Moneyline)	+128	-161
Line (Spread)	+3.5 (-110)	-3.5 (-115)
Total	o40.5 (-108)	u40.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Panthers vs. Raiders game-day updates and essential details

Friday's Australian rugby league action between the Panthers and Raiders at Panthers Stadium is scheduled to start at 4:00AM ET.

• Who: Canberra Raiders vs. Penrith Panthers
• Date: Friday, August 22, 2025
• Time: 4:00AM ET/1:00AM PT
• Venue: Panthers Stadium

The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.

Dimers.com's full preview of Friday's Raiders vs. Panthers matchup includes our prediction, picks and the latest betting odds.

Before making any Raiders vs. Panthers picks, be sure to check out the latest NRL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Panthers, with a 69% win probability, will likely beat the Raiders on Friday.

AI and automation have enhanced this article to quickly deliver accurate Raiders vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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