Butler vs. DePaul Prediction: Butler Predicted to Win College Basketball Matchup [2/22/2025]

DePaul and Butler will lock horns in college basketball action at Wintrust Arena on Saturday, starting at 8:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model (see Dimers Pro for full access) projects Butler as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has used the latest data to run 10,000 simulations of Saturday's Butler-DePaul game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that Butler is more likely to win, while DePaul has a lower chance of victory."

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Butler vs. DePaul predictions page.

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Butler vs. DePaul Prediction: Who Will Win, Cover the Spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball matchup between Butler and DePaul 10,000 times as part of our college basketball predictions coverage.

Our independent predictive model currently gives Butler a 60% chance of defeating DePaul. Our predicted final score has Butler winning 74-71.

According to our model, DePaul (+3.5) has a 56% chance of covering the spread, while the over/under total of 147.5 points has a 53% chance of staying under.

Butler vs. DePaul Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

Bet Type	Butler	DePaul
Spread	-3.5 (-110)	+3.5 (-105)
Moneyline	-172	+154
Total	o147.5 (-105)	u147.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Butler vs. DePaul Picks and Best Bets

Our model's strongest edge in today's Butler vs. DePaul matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Butler vs. DePaul Game-Day Updates and Essential Details

Saturday's college basketball game between DePaul and Butler at Wintrust Arena is scheduled to start at 8:00PM ET.

• Who: Butler vs. DePaul
• Date: Saturday, February 22, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Wintrust Arena

Dimers.com's in-depth preview of Saturday's Butler vs. DePaul matchup includes our prediction, picks and the latest betting odds.

Before making any Butler vs. DePaul picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Butler, with a 60% win probability, will likely beat DePaul on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Butler vs. DePaul insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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