Buffalo vs. Minnesota prediction: Why Minnesota is favored to win in college football Week 1, 2025

Minnesota will square off with Buffalo in college football action at Huntington Bank Stadium on Thursday, commencing at 8:00PM ET.

Based on updated simulation results, Dimers' advanced college football model predicts Minnesota as the most likely winner of today's game.

For a closer look at Thursday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Buffalo vs. Minnesota predictions page.

Buffalo vs. Minnesota prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Buffalo vs. Minnesota 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Minnesota a 90% chance of beating Buffalo. Our predicted final score has Minnesota winning 31-14.

According to our model, the bookmakers have got it right, and Buffalo and Minnesota each have a 50% chance of covering the spread, while the over/under total of 42.5 points has a 56% chance of staying under.

Buffalo vs. Minnesota odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Buffalo	Minnesota
Spread	+16.5 (-110)	-16.5 (-105)
Moneyline	+590	-750
Total	o42.5 (-110)	u42.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Buffalo vs. Minnesota picks and best bets

Our model's strongest edge in today's Buffalo vs. Minnesota matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Buffalo vs. Minnesota game-day updates and essential details

Thursday's college football game between Minnesota and Buffalo at Huntington Bank Stadium is scheduled to commence at 8:00PM ET.

• Who: Buffalo vs. Minnesota
• Date: Thursday, August 28, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Huntington Bank Stadium

Dimers.com's full preview of Thursday's Buffalo vs. Minnesota matchup includes our prediction, picks and the latest betting odds.

Before making any Buffalo vs. Minnesota picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Minnesota, with a 90% win probability, will likely beat Buffalo on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Buffalo vs. Minnesota insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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