Buffalo Bills vs. New York Jets early prediction: Expert picks for NFL Week 2, 2025

The Buffalo Bills and New York Jets will meet in Week 2 of the NFL season at MetLife Stadium on Sunday, September 14, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Jets predictions page.

Buffalo vs. NY Jets early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Jets game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 76%, Jets 24%
• Predicted final score: Bills 25-18 Jets
• Spread: Bills (-8.5) 43%, Jets (+8.5) 57%
• Total points (44.5): Over 50%, Under 50%

As of September 7, 2025, these Bills-Jets figures and predictions reflect the latest data and insights available.

Bills vs. Jets Week 2 details

The NFL Week 2 action between the Jets and Bills at MetLife Stadium is scheduled for September 14, 2025.

• Who: Buffalo Bills vs. New York Jets
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: MetLife Stadium

Bills vs. Jets opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Bills -8.5 (-110), Jets +8.5 (-110)
• Moneyline: Bills -400, Jets +320
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 76% win probability, will likely beat the Jets in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Jets matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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