BYU vs. Colorado prediction: Why Brigham Young is favored to win in college football Week 5, 2025

Colorado and Brigham Young will lock horns in Week 5 college football action at Folsom Field on Saturday, commencing at 10:15PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Brigham Young as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive BYU vs. Colorado predictions page.

BYU vs. Colorado prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of BYU vs. Colorado 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Brigham Young a 68% chance of beating Colorado. Our predicted final score has Brigham Young winning 27-21.

According to our model, the bookmakers have got it right, and Brigham Young and Colorado each have a 50% chance of covering the spread, while the 48.5-point over/under has a 52% chance of going over.

BYU vs. Colorado odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	BYU	Colorado
Spread	-6.5 (-110)	+6.5 (-104)
Moneyline	-235	+205
Total	o48.5 (-108)	u48.5 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

BYU vs. Colorado picks and best bets

Our model's biggest edge in today's BYU vs. Colorado matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

BYU vs. Colorado game-day updates and essential details

Saturday's college football action between Colorado and BYU at Folsom Field is scheduled to commence at 10:15PM ET.

• Who: Brigham Young vs. Colorado
• Date: Saturday, September 27, 2025
• Time: 10:15PM ET/7:15PM PT
• Venue: Folsom Field

Dimers' comprehensive preview of Saturday's BYU vs. Colorado matchup includes our prediction, picks and the latest betting odds.

Before making any BYU vs. Colorado picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Brigham Young, with a 68% win probability, will likely beat Colorado on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Brigham Young vs. Colorado insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most up-to-date projections for the national title game and major conferences.