Botic Van de Zandschulp vs. Holger Rune prediction, odds, picks for US Open 2025

Botic Van de Zandschulp will face Holger Rune in the first round of the US Open Men's Singles 2025 on Monday.

Based on updated simulation results, Dimers' proven tennis model predicts Holger Rune as the most likely winner of the match.

For expanded analysis of Monday's match, including best bets and picks, visit our interactive Van de Zandschulp vs. Rune predictions page.

Van de Zandschulp vs. Rune prediction: Who will win and advance to the Second Round?

Using trusted machine learning and data analysis, we have simulated the result of Monday's Van de Zandschulp-Rune men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model currently gives Rune a 72% chance of winning against Van de Zandschulp in the US Open 2025.

Additionally, Rune has a 66% chance of winning the first set. The simulations also show Rune (-4.5) has a 53% chance of covering the games spread, while the under 37.5 games has a 54% chance of hitting, according to our model.

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Botic Van de Zandschulp vs. Holger Rune odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Van de Zandschulp	Rune
Moneyline	+250	-285
First Set	+175	-227
Game Spread	-4.5 (-155)	+4.5 (-105)
Total Games	o37.5 (-115)	u37.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Van de Zandschulp vs. Rune picks and best bets

Our model's biggest edge in today's Van de Zandschulp vs. Rune match is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Van de Zandschulp vs. Rune updates and essential details

The US Open 2025 match between Botic Van de Zandschulp and Holger Rune is scheduled to begin on Monday at 3:10PM ET.

• Who: Botic Van de Zandschulp vs. Holger Rune
• Date: Monday, August 25, 2025
• Approx. Time: 3:10PM ET/12:10PM PT
• Tournament: US Open Men's Singles 2025
• Round: First round

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Dimers.com's full preview of Monday's Van de Zandschulp vs. Rune match includes our prediction, picks and the latest betting odds.

Before making any Botic Van de Zandschulp vs. Holger Rune picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Holger Rune, with a 72% win probability, will likely beat Botic Van de Zandschulp at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Van de Zandschulp vs. Rune insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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