Red Sox vs. Rays prediction: Why Boston is favored to win Saturday's MLB matchup [9/20/2025]

The Tampa Bay Rays will take on the Boston Red Sox in MLB action at George M. Steinbrenner Field on Saturday, beginning at 7:05PM ET.

Adrian Houser (8-4, 3.11 ERA) will be the starting pitcher for the Rays, while the Red Sox are going with Kyle Harrison (1-1, 4.05 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Red Sox vs. Rays predictions page.

Rays vs. Red Sox prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the Red Sox and Rays 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Red Sox a 52% chance of defeating the Rays.

According to our model, the Rays (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Red Sox vs. Rays odds [9/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Rays
Run Line	-1.5 (+158)	+1.5 (-188)
Moneyline	-104	-110
Total	o8 (-102)	u8 (-115)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Rays picks and best bets

Our model's strongest edge in today's Red Sox vs. Rays matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Red Sox vs. Rays game-day updates and essential details

Saturday's MLB game between the Rays and Red Sox at George M. Steinbrenner Field is scheduled to begin at 7:05PM ET.

• Who: Boston Red Sox vs. Tampa Bay Rays
• Date: Saturday, September 20, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: George M. Steinbrenner Field

Dimers' comprehensive preview of Saturday's Red Sox vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 52% win probability, will likely beat the Rays on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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