Red Sox vs. Rays Prediction: Tampa Bay Predicted to Win Wednesday's MLB Matchup [4/16/2025]

The Tampa Bay Rays will square off with the Boston Red Sox, in what is expected to be a tight MLB game, at George M. Steinbrenner Field on Wednesday, beginning at 7:05PM ET.

Zack Littell (0-3, 6.88 ERA) will start on the mound for the Rays, up against Sean Newcomb (0-2, 4.97 ERA) for the Red Sox.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Rays as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Boston-Tampa Bay game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Rays' chance of winning at 54%, with the Red Sox at 46%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Red Sox vs. Rays predictions page.

Red Sox vs. Red Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Red Sox and Rays 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Rays a 54% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 53% chance of going over.

Red Sox vs. Rays Odds [4/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Rays
Run Line	+1.5 (-166)	-1.5 (+155)
Moneyline	+124	-135
Total	o8.5 (-120)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Rays Picks and Best Bets

Our model's strongest edge in today's Red Sox vs. Rays matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Red Sox vs. Rays Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Rays and Red Sox at George M. Steinbrenner Field is scheduled to commence at 7:05PM ET.

• Who: Boston Red Sox vs. Tampa Bay Rays
• Date: Wednesday, April 16, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: George M. Steinbrenner Field

Dimers.com's comprehensive preview of Wednesday's Red Sox vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Boston vs. Tampa Bay picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Rays, with a 54% win probability, will likely beat the Red Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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