Red Sox vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [8/8/2025]

The San Diego Padres will take on the Boston Red Sox in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

Nick Pivetta (11-3, 2.73 ERA) will be on the bump for the Padres, up against Walker Buehler (6-6, 5.74 ERA) for the Red Sox.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Red Sox vs. Padres predictions page.

Padres vs. Red Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Red Sox and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 61% chance of defeating the Red Sox.

According to our model, the Red Sox (+1.5) have a 57% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Red Sox vs. Padres Odds [8/8/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Padres
Run Line	+1.5 (-136)	-1.5 (+118)
Moneyline	+150	-175
Total	o8 (-120)	u8 (+100)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Padres Picks and Best Bets

Our model's strongest edge in today's Red Sox vs. Padres matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

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Red Sox vs. Padres Game-Day Updates and Essential Details

Friday's MLB matchup between the Padres and Red Sox at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Boston Red Sox vs. San Diego Padres
• Date: Friday, August 8, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Friday's Red Sox vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Red Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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