Red Sox vs. Yankees prediction: Yankees favored to win Thursday's MLB matchup [8/21/2025]

The New York Yankees will take on the Boston Red Sox in MLB action at Yankee Stadium on Thursday, beginning at 7:15PM ET.

The Yankees will start Luis Gil (1-1, 5.14 ERA), pitting him against Lucas Giolito (8-2, 3.63 ERA) for the Red Sox.

Based on the latest simulations, Dimers' advanced MLB model projects the Yankees as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Red Sox vs. Yankees predictions page.

Yankees vs. Red Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Red Sox and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 60% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 59% chance of covering the run line, while the 8.5-run over/under has a 52% chance of going over.

Red Sox vs. Yankees odds [8/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Yankees
Run Line	+1.5 (-170)	-1.5 (+145)
Moneyline	+125	-144
Total	o8.5 (-115)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Yankees picks and best bets

Our model's strongest edge in today's Red Sox vs. Yankees matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Red Sox vs. Yankees game-day updates and essential details

Thursday's MLB action between the Yankees and Red Sox at Yankee Stadium is scheduled to begin at 7:15PM ET.

• Who: Boston Red Sox vs. New York Yankees
• Date: Thursday, August 21, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Yankee Stadium

Dimers.com's full preview of Thursday's Red Sox vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 60% win probability, will likely beat the Red Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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