Red Sox vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [8/22/2025]

The New York Yankees will square off with the Boston Red Sox in MLB action at Yankee Stadium on Friday, starting at 7:05PM ET.

The Yankees will start Max Fried (13-5, 3.26 ERA), up against Brayan Bello (9-6, 3.23 ERA) for the Red Sox.

Based on updated simulations, Dimers' advanced MLB model projects the Yankees as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Red Sox vs. Yankees predictions page.

Yankees vs. Red Sox prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Red Sox and Yankees 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Yankees a 64% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 53% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Red Sox vs. Yankees odds [8/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Yankees
Run Line	+1.5 (-125)	-1.5 (+105)
Moneyline	+164	-190
Total	o8.5 (-106)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Yankees picks and best bets

Our model's biggest edge in today's Red Sox vs. Yankees matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Red Sox vs. Yankees game-day updates and essential details

Friday's MLB action between the Yankees and Red Sox at Yankee Stadium is scheduled to begin at 7:05PM ET.

• Who: Boston Red Sox vs. New York Yankees
• Date: Friday, August 22, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers.com's comprehensive preview of Friday's Red Sox vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 64% win probability, will likely beat the Red Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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