Red Sox vs. Astros Prediction: Houston Predicted to Win Wednesday's MLB Matchup [8/13/2025]

The Houston Astros will take on the Boston Red Sox in MLB action at Daikin Park on Wednesday, starting at 7:10PM ET.

Hunter Brown (9-5, 2.51 ERA) will start for the Astros, up against Walker Buehler (7-6, 5.40 ERA) for the Red Sox.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game. "Our team has simulated the outcome of Wednesday's Red Sox-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 59%, with the Red Sox at 41%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Red Sox vs. Astros predictions page.

Astros vs. Red Sox Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Red Sox and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 59% chance of defeating the Red Sox.

According to our model, the Red Sox (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of staying under.

Red Sox vs. Astros Odds [8/13/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Astros
Run Line	+1.5 (-158)	-1.5 (+140)
Moneyline	+133	-150
Total	o8 (-105)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Red Sox vs. Astros Picks and Best Bets

Our model's biggest edge in today's Red Sox vs. Astros matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Red Sox vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB game between the Astros and Red Sox at Daikin Park is scheduled to start at 7:10PM ET.

• Who: Boston Red Sox vs. Houston Astros
• Date: Wednesday, August 13, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Daikin Park

Dimers.com's comprehensive preview of Wednesday's Red Sox vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 59% win probability, will likely beat the Red Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most up-to-date projections for the World Series, American League, National League and each division.