Red Sox vs. Orioles prediction: Boston favored to win Wednesday's MLB matchup [8/27/2025]

The Baltimore Orioles and Boston redsox will meet in MLB action at Oriole Park at Camden Yards on Wednesday, starting at 6:35PM ET.

Dietrich Enns (1-2, 4.97 ERA) will start for the Orioles, while the Red Sox have opted for Brayan Bello (10-6, 3.07 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Red Sox as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Red Sox-Orioles game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Red Sox' chance of winning at 54%, with the Orioles at 46%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Red Sox vs. Orioles predictions page.

Orioles vs. Red Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Red Sox and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Red Sox a 54% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 59% chance of covering the run line, while the 9-run over/under has a 53% chance of staying under.

Red Sox vs. Orioles odds [8/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Orioles
Run Line	-1.5 (+116)	+1.5 (-135)
Moneyline	-138	+120
Total	o9 (-102)	u9 (-118)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Orioles picks and best bets

Our model's biggest edge in today's Red Sox vs. Orioles matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Red Sox vs. Orioles game-day updates and essential details

Wednesday's MLB action between the Orioles and Red Sox at Oriole Park at Camden Yards is scheduled to begin at 6:35PM ET.

• Who: Boston Red Sox vs. Baltimore Orioles
• Date: Wednesday, August 27, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers.com's comprehensive preview of Wednesday's Red Sox vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 54% win probability, will likely beat the Orioles on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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