Red Sox vs. Diamondbacks prediction: Why Boston is favored to win Saturday's MLB matchup [9/6/2025]

The Arizona Diamondbacks will take on the Boston Red Sox in MLB action at Chase Field on Saturday, starting at 8:10PM ET.

Brandon Pfaadt (12-8, 5.33 ERA) will be on the bump for the Diamondbacks, up against Lucas Giolito (10-2, 3.38 ERA) for the Red Sox.

Based on updated simulation results, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Red Sox vs. Diamondbacks predictions page.

Diamondbacks vs. Red Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB game between the Red Sox and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Red Sox a 51% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 61% chance of covering the run line, while the over/under total of 9 runs has a 51% chance of going over.

Red Sox vs. Diamondbacks odds [9/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Diamondbacks
Run Line	-1.5 (+135)	+1.5 (-156)
Moneyline	-120	+102
Total	o9 (-110)	u9 (-108)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Red Sox vs. Diamondbacks matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Red Sox vs. Diamondbacks game-day updates and essential details

Saturday's MLB game between the Diamondbacks and Red Sox at Chase Field is scheduled to start at 8:10PM ET.

• Who: Boston Red Sox vs. Arizona Diamondbacks
• Date: Saturday, September 6, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Chase Field

Dimers.com's in-depth preview of Saturday's Red Sox vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 51% win probability, will likely beat the Diamondbacks on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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