Red Sox vs. Diamondbacks prediction: Why Boston is favored to win Friday's MLB matchup [9/5/2025]

The Arizona Diamondbacks and Boston redsox are scheduled to meet in MLB action at Chase Field on Friday, starting at 9:40PM ET.

The Diamondbacks will send Eduardo Rodriguez (6-8, 5.40 ERA) to the mound, while the Red Sox are going with Payton Tolle (0-0, 3.38 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Red Sox vs. Diamondbacks predictions page.

Diamondbacks vs. Red Sox prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Red Sox and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Red Sox a 54% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 60% chance of covering the run line, while the over/under total of 9 runs has a 52% chance of staying under.

Red Sox vs. Diamondbacks odds [9/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Red Sox	Diamondbacks
Run Line	-1.5 (+125)	+1.5 (-144)
Moneyline	-130	+114
Total	o9 (-105)	u9 (-115)

All odds are correct at the time of publication and are subject to change.

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Red Sox vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Red Sox vs. Diamondbacks matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Red Sox vs. Diamondbacks game-day updates and essential details

Friday's MLB matchup between the Diamondbacks and Red Sox at Chase Field is scheduled to begin at 9:40PM ET.

• Who: Boston Red Sox vs. Arizona Diamondbacks
• Date: Friday, September 5, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Friday's Red Sox vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Red Sox vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Red Sox, with a 54% win probability, will likely beat the Diamondbacks on Friday.

AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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