Bills vs. Saints Predictions and Odds - Nov 25, 2021

The New Orleans Saints and Buffalo Bills clash in Week 12 of the NFL season at Caesars Superdome on Thanksgiving Day, with kickoff at 8:20 PM EST.

Dimers' free betting picks for Bills vs. Saints, plus game predictions and best odds, are featured below.

Who will win Bills vs. Saints?

Based on advanced machine learning and data, Dimers.com has simulated Thursday's Bills-Saints game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Bills a 72% chance of beating the Saints.

MORE: Bills vs. Saints Simulated 10,000 Times

Bills vs. Saints Point Spread, Moneyline and Over/Under

The Saints are currently +7 underdogs against the Bills, with -110 at Caesars Sportsbook the best odds available.

For the favored Bills (-7) to cover the spread, PointsBet has the best odds on offer at -105.

FanDuel Sportsbook has the best moneyline odds for the Saints at +245, which means you can throw down $100 to profit $245, earning a total payout of $345, if they win.

Meanwhile, FanDuel Sportsbook also has the best moneyline odds for the Bills at -300, where you can risk $300 to win $100, for a total payout of $400, if they come out on top.

The Over/Under for total points scored is set at 44.5 with PointsBet, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the Saints (+7) are a 57% chance of covering the spread, while the 44.5-point Over/Under is a 52% chance of going Over.

MORE: Super Bowl LVI Probabilities and Odds

Best Bets for Bills vs. Saints

• Spread: Saints +7 at -110 with Caesars Sportsbook (57% probability) 🔥
• Moneyline: Saints Win at +245 with FanDuel Sportsbook
• Over/Under: Over 44.5 at -110 with PointsBet (52% probability)

When you see a 🔥, you know you've found one of our best free picks today across any sport.

While the Bills are more likely to win the game, according to DimersBOT, taking the Saints moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds.

Taking advantage of the edges published on Dimers.com is crucial to achieving long-term profitability.

Bills vs. Saints Score Prediction

Dimers.com's predicted final score for Buffalo vs. New Orleans at Caesars Superdome this Thursday has the Bills winning 25-19.

Use our widget below to see the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's Bills-Saints matchup, including pre-game predictions, free picks, and live scores.

Remember, DimersBOT updates often, so keep an eye on this page for the latest betting insights before Bills vs. Saints on Thursday November 25, 2021.

Bills vs. Saints 2021 Game Info

When do the Saints play the Bills?

• Date: Thursday November 25, 2021
• Time: 8:20 PM EST / 5:20 PM PST
• Venue: Caesars Superdome

Ready to join an online sportsbook and start betting on the NFL? We've listed the best available welcome offers in every legal betting state.

What other NFL games are on today?

The Bills and Saints aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every NFL game in our NFL Bet Hub page.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!