Best bets today for all sports: Sunday's picks revealed [9/21/2025]

Today’s sports betting picks for September 21, 2025 are here, with Sunday’s best bets powered by tens of thousands of data simulations analyzing the latest odds and matchups.

Today's best bets will be sourced from matchups such as Nationals vs. Braves in the MLB, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

Pro members get unlimited access to everything Dimers has to offer, including our full set of picks and best bets for today and the week ahead.

List of best bets for today [9/21, updated 11:31PM ET]

Having simulated today's remaining games 10,000 times, our model has concluded that there are no best bets worth making at this time. This is due to the lack of favorable edges between our data-driven probabilities and the best available odds.

List of upcoming matchups to bet on now [9/21/2025]

• MLB: Nationals vs. Braves (7:15PM ET, Monday)
• NFL: Lions vs. Ravens (8:15PM ET, Monday)
• MLB: Brewers vs. Padres (9:40PM ET, Monday)
• MLB: Cardinals vs. Giants (9:45PM ET, Monday)

See How Dimers Pro Enhances Your Best Bets

Discover the difference our best bets make with Dimers Pro. Check out this explainer video to see how you can gain an edge.

Bet365 bonus code "DIMERS" — perfect for Sunday betting

To make the most of Sunday's best bets, including the matchup, check out the new Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet – win or lose. Don't miss out!

Conclusion

Our best bets are locked and loaded for September 21, 2025, with our in-house predictive analytics model constantly searching for bets across Sunday's action.. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.