Best bets today for all sports: Monday's picks revealed [9/22/2025]

Today’s sports betting picks for September 22, 2025 are here, with Monday’s best bets built on tens of thousands of predictive simulations analyzing the latest odds and matchups.

Today's best bets will be sourced from matchups such as Alejandro Tabilo vs. Lorenzo Musetti in the Tennis, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

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List of best bets for today [9/22, updated 11:31PM ET]

Having simulated today's remaining action 10K times, our model has concluded that there are no best bets worth making right now. This is due to the lack of valuable edges between our data-driven probabilities and the top available odds.

List of upcoming matchups to bet on right now [9/22/2025]

• Tennis: Alejandro Tabilo vs. Lorenzo Musetti (7:00AM ET, Tuesday)
• Tennis: Alexander Bublik vs. Valentin Royer (7:30AM ET, Tuesday)
• La Liga: Valencia vs. Espanyol (1:00PM ET, Tuesday)
• La Liga: Girona vs. Athletic Bilbao (1:00PM ET, Tuesday)
• La Liga: Villareal vs. Sevilla (3:30PM ET, Tuesday)
• La Liga: Real Madrid vs. Levante (3:30PM ET, Tuesday)
• MLB: Rays vs. Orioles (6:35PM ET, Tuesday)
• MLB: Tigers vs. Guardians (6:40PM ET, Tuesday)
• MLB: Pirates vs. Reds (6:40PM ET, Tuesday)
• MLB: Marlins vs. Phillies (6:45PM ET, Tuesday)

Conclusion

Our best bets are locked and loaded for September 22, 2025, with our in-house predictive analytics model constantly searching for bets across Monday's action.. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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