Baltimore Ravens vs. Buffalo Bills early prediction: Expert picks for NFL Week 1, 2025

The Baltimore Ravens and Buffalo Bills will meet in Week 1 of the NFL season at Highmark Stadium on Sunday, September 7, 2025, starting at 8:20PM ET.

Early simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Ravens vs. Bills predictions page.

Baltimore vs. Buffalo early predictions

Leveraging trusted machine learning and analysis, we have simulated the Ravens vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Ravens 46%, Bills 54%
• Predicted final score: Ravens 25-26 Bills
• Spread: Ravens (+1.5) 50%, Bills (-1.5) 50%
• Total points (52.5): Over 46%, Under 54%

As of August 31, 2025, these Ravens-Bills numbers and predictions reflect the latest data and insights available.

Ravens vs. Bills Week 1 details

The NFL Week 1 action between the Bills and Ravens at Highmark Stadium is scheduled for September 7, 2025.

• Who: Baltimore Ravens vs. Buffalo Bills
• Date: Sunday, September 7, 2025
• Time: 8:20PM ET/5:20PM PT
• Venue: Highmark Stadium

Ravens vs. Bills opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Ravens +1.5 (-118), Bills -1.5 (+100)
• Moneyline: Ravens -105, Bills -108
• Total: Over/Under 52.5 (-102/-120)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 54% win probability, will likely beat the Ravens in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Ravens vs. Bills game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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