Orioles vs. Nationals Prediction: Baltimore Predicted to Win Wednesday's MLB Matchup [4/23/2025]

The Washington Nationals will square off with the Baltimore Orioles in MLB action at Nationals Park on Wednesday, starting at 6:45PM ET.

Trevor Williams (1-2, 5.95 ERA) will get the ball for the Nationals, up against Tomoyuki Sugano (2-1, 3.43 ERA) for the Orioles.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Orioles as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Baltimore-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Orioles' chance of winning at 55%, with the Nationals at 45%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Orioles vs. Nationals predictions page.

Nationals vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Orioles and Nationals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Orioles a 55% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 56% chance of covering the run line, while the over/under total of 9.5 runs has a 52% chance of staying under.

Orioles vs. Nationals Odds [4/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Nationals
Run Line	-1.5 (+125)	+1.5 (-132)
Moneyline	-140	+124
Total	o9.5 (-102)	u9.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Orioles vs. Nationals matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Orioles vs. Nationals Game-Day Updates and Essential Details

Wednesday's MLB game between the Nationals and Orioles at Nationals Park is scheduled to commence at 6:45PM ET.

• Who: Baltimore Orioles vs. Washington Nationals
• Date: Wednesday, April 23, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's comprehensive preview of Wednesday's Orioles vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Baltimore vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Orioles, with a 55% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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