Orioles vs. Blue Jays prediction: Why Toronto is favored to win Friday's MLB matchup [9/12/2025]

The Toronto Blue Jays will take on the Baltimore Orioles in MLB action at Rogers Centre on Friday, commencing at 7:07PM ET.

The Blue Jays will send Chris Bassitt (11-8, 3.97 ERA) to the mound, pitting him against Trevor Rogers (8-2, 1.50 ERA) for the Orioles.

Based on updated simulation results, Dimers' advanced MLB model predicts the Blue Jays as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Orioles vs. Blue Jays predictions page.

Blue Jays vs. Orioles prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Friday's MLB game between the Orioles and Blue Jays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Blue Jays a 56% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 63% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Orioles vs. Blue Jays odds [9/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Blue Jays
Run Line	+1.5 (-184)	-1.5 (+158)
Moneyline	+115	-132
Total	o7.5 (-109)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Blue Jays picks and best bets

Our model's strongest edge in today's Orioles vs. Blue Jays matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Orioles vs. Blue Jays game-day updates and essential details

Friday's MLB matchup between the Blue Jays and Orioles at Rogers Centre is scheduled to begin at 7:07PM ET.

• Who: Baltimore Orioles vs. Toronto Blue Jays
• Date: Friday, September 12, 2025
• Time: 7:07PM ET/4:07PM PT
• Venue: Rogers Centre

Dimers' full preview of Friday's Orioles vs. Blue Jays matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Blue Jays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Blue Jays, with a 56% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Blue Jays insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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