Orioles vs. Giants prediction: San Francisco favored to win Friday's MLB matchup [8/29/2025]

MLB action continues on Friday at 10:15PM ET as the Baltimore Orioles lock horns with the San Francisco Giants at Oracle Park.

Robbie Ray (10-6, 2.93 ERA) will start on the mound for the Giants, while the Orioles are going with Dean Kremer (9-9, 4.20 ERA).

Based on the latest simulations, Dimers' proven MLB model projects the Giants as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Orioles vs. Giants predictions page.

Giants vs. Orioles prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Orioles and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 58% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Orioles vs. Giants odds [8/29/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Giants
Run Line	+1.5 (-184)	-1.5 (+154)
Moneyline	+125	-142
Total	o7.5 (-105)	u7.5 (-112)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Orioles vs. Giants picks and best bets

Our model's biggest edge in today's Orioles vs. Giants matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Orioles vs. Giants game-day updates and essential details

Friday's MLB action between the Giants and Orioles at Oracle Park is scheduled to begin at 10:15PM ET.

• Who: Baltimore Orioles vs. San Francisco Giants
• Date: Friday, August 29, 2025
• Time: 10:15PM ET/7:15PM PT
• Venue: Oracle Park

Dimers.com's full preview of Friday's Orioles vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Friday

To make the most of Friday's exciting day of sports, headlined by continued college football Week 1 action, check out details on the latest Bet365 bonus code "DIMERS" that grants you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Giants, with a 58% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date projections for the World Series, American League, National League and each division.