Orioles vs. Padres prediction: San Diego favored to win Wednesday's MLB matchup [9/3/2025]

The San Diego Padres and Baltimore Orioles will meet in MLB action at PETCO Park on Wednesday, starting at 4:10PM ET.

Nestor Cortes (2-3, 5.06 ERA) will be on the bump for the Padres, while the Orioles have opted for Cade Povich (2-7, 5.04 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Orioles-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 61%, with the Orioles at 39%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Orioles vs. Padres predictions page.

Padres vs. Orioles prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Orioles and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 61% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 57% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Orioles vs. Padres odds [9/3/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Padres
Run Line	+1.5 (-130)	-1.5 (+113)
Moneyline	+158	-187
Total	o8.5 (+100)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Padres picks and best bets

Our model's strongest edge in today's Orioles vs. Padres matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Orioles vs. Padres game-day updates and essential details

Wednesday's MLB action between the Padres and Orioles at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: Baltimore Orioles vs. San Diego Padres
• Date: Wednesday, September 3, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Wednesday's Orioles vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Orioles on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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