Orioles vs. Padres prediction: San Diego favored to win Tuesday's MLB matchup [9/2/2025]

The San Diego Padres will square off with the Baltimore Orioles in MLB action at PETCO Park on Tuesday, beginning at 9:40PM ET.

The Padres will start Yu Darvish (3-4, 5.66 ERA), pitting him against Tyler Wells (0-0, 0.00 ERA) for the Orioles.

Based on updated simulation results, Dimers' advanced MLB model projects the Padres as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Orioles vs. Padres predictions page.

Padres vs. Orioles prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Orioles and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 63% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 57% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Orioles vs. Padres odds [9/2/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Padres
Run Line	+1.5 (-142)	-1.5 (+125)
Moneyline	+146	-174
Total	o8 (-115)	u8 (-103)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Padres picks and best bets

Our model's biggest edge in today's Orioles vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Orioles vs. Padres game-day updates and essential details

Tuesday's MLB action between the Padres and Orioles at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Baltimore Orioles vs. San Diego Padres
• Date: Tuesday, September 2, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Tuesday's Orioles vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 63% win probability, will likely beat the Orioles on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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