...
...
Read Article
Orioles vs. Padres prediction: San Diego favored to win Labor Day MLB matchup [9/1/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Baltimore Orioles vs San Diego Padres predictions for MLB Labor Day.
The San Diego Padres will face the Baltimore Orioles in MLB action at PETCO Park on Monday, beginning at 6:40PM ET.
The Padres will have Dylan Cease (6-11, 4.82 ERA) as their starting pitcher, while the Orioles will counter with Kyle Bradish (0-1, 3.00 ERA).
Based on updated simulations, Dimers' advanced MLB model projects the Padres as the most likely winner of today's game.
For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Orioles vs. Padres predictions page.
Padres vs. Orioles prediction: Who will win, cover the run line?
Using trusted machine learning and statistical analysis, we have simulated the result of Monday's MLB matchup between the Orioles and Padres 10,000 times as part of our MLB predictions coverage.
Our independent predictive model currently gives the Padres a 63% chance of beating the Orioles.
According to our model, the Orioles (+1.5) have a 58% chance of covering the run line, while the 7.5-run over/under has a 51% chance of staying under.
Orioles vs. Padres odds [9/1/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Orioles | Padres |
|---|---|---|
| Run Line | +1.5 (-160) | -1.5 (+137) |
| Moneyline | +140 | -158 |
| Total | o7.5 (+100) | u7.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Orioles vs. Padres picks and best bets
Our model's strongest edge in today's Orioles vs. Padres matchup is on the moneyline.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's free MLB picks
Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.
Orioles vs. Padres game-day updates and essential details
Monday's MLB game between the Padres and Orioles at PETCO Park is scheduled to begin at 6:40PM ET.
- Who: Baltimore Orioles vs. San Diego Padres
- Date: Monday, September 1, 2025
- Time: 6:40PM ET/3:40PM PT
- Venue: PETCO Park
Dimers.com's full preview of Monday's Orioles vs. Padres matchup includes our prediction, picks and the latest betting odds.
Before making any Orioles vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Padres, with a 63% win probability, will likely beat the Orioles on Monday.
AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on MLB
Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure