Orioles vs. Yankees prediction: Yankees favored to win Sunday's MLB matchup [9/28/2025]

The New York Yankees will face the Baltimore Orioles in MLB action at Yankee Stadium on Sunday, starting at 3:05PM ET.

Luis Gil (4-1, 3.29 ERA) will be on the bump for the Yankees, pitting him against Kyle Bradish (1-1, 2.25 ERA) for the Orioles.

Based on updated simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Orioles-Yankees game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Yankees with a win probability of 62%, while the Orioles have 38%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Orioles vs. Yankees predictions page.

Yankees vs. Orioles prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB matchup between the Orioles and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 62% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 56% chance of covering the run line, while the 8.5-run over/under has a 61% chance of going over.

Orioles vs. Yankees odds [9/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Yankees
Run Line	+1.5 (-145)	-1.5 (+125)
Moneyline	+145	-168
Total	o8.5 (-120)	u8.5 (+104)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Orioles vs. Yankees picks and best bets

Our model's strongest edge in today's Orioles vs. Yankees matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Orioles vs. Yankees game-day updates and essential details

Sunday's MLB game between the Yankees and Orioles at Yankee Stadium is scheduled to commence at 3:05PM ET.

• Who: Baltimore Orioles vs. New York Yankees
• Date: Sunday, September 28, 2025
• Time: 3:05PM ET/12:05PM PT
• Venue: Yankee Stadium

Dimers' full preview of Sunday's Orioles vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 62% win probability, will likely beat the Orioles on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest predictions for the World Series, American League, National League and each division.