...
...
Read Article
Orioles vs. Yankees prediction: Yankees favored to win Saturday's MLB matchup [9/27/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Baltimore Orioles vs New York Yankees predictions for MLB Saturday.
The New York Yankees and Baltimore Orioles are scheduled to meet in MLB action at Yankee Stadium on Saturday, starting at 1:05PM ET.
Cam Schlittler (3-3, 3.27 ERA) will be on the bump for the Yankees, pitting him against Tomoyuki Sugano (10-9, 4.54 ERA) for the Orioles.
Based on updated simulation results, Dimers' proven MLB model projects the Yankees as the most likely winner of today's game.
For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Orioles vs. Yankees predictions page.
Yankees vs. Orioles prediction: Who will win, cover the run line?
Using powerful machine learning and statistical analysis, we have simulated the result of Saturday's MLB matchup between the Orioles and Yankees 10,000 times as part of our MLB predictions coverage.
Our independent predictive model currently gives the Yankees a 68% chance of defeating the Orioles.
According to our model, the Yankees (-1.5) have a 51% chance of covering the run line, while the over/under total of 9 runs has a 59% chance of going over.
Orioles vs. Yankees odds [9/27/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Orioles | Yankees |
|---|---|---|
| Run Line | +1.5 (-102) | -1.5 (-110) |
| Moneyline | +198 | -225 |
| Total | o9 (-105) | u9 (-110) |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Orioles vs. Yankees picks and best bets
Our model's biggest edge in today's Orioles vs. Yankees matchup is on the run line.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's free ⚾️ picks
Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.
Orioles vs. Yankees game-day updates and essential details
Saturday's MLB game between the Yankees and Orioles at Yankee Stadium is scheduled to start at 1:05PM ET.
- Who: Baltimore Orioles vs. New York Yankees
- Date: Saturday, September 27, 2025
- Time: 1:05PM ET/10:05AM PT
- Venue: Yankee Stadium
Dimers' full preview of Saturday's Orioles vs. Yankees matchup includes our prediction, picks and the latest betting odds.
Before making any Orioles vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Yankees, with a 68% win probability, will likely beat the Orioles on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on MLB
Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
Advertiser disclosure