Orioles vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [9/26/2025]

MLB action continues on Friday at 7:05PM ET as the Baltimore Orioles lock horns with the New York Yankees at Yankee Stadium.

The Yankees will start Will Warren (8-8, 4.35 ERA), while the Orioles will counter with Trevor Rogers (9-2, 1.35 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Yankees as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Orioles vs. Yankees predictions page.

Yankees vs. Orioles prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Orioles and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Yankees a 57% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has a 56% chance of going over.

Orioles vs. Yankees odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Yankees
Run Line	+1.5 (-175)	-1.5 (+146)
Moneyline	+125	-142
Total	o8.5 (-105)	u8.5 (-109)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Yankees picks and best bets

Our model's biggest edge in today's Orioles vs. Yankees matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Orioles vs. Yankees game-day updates and essential details

Friday's MLB matchup between the Yankees and Orioles at Yankee Stadium is scheduled to commence at 7:05PM ET.

• Who: Baltimore Orioles vs. New York Yankees
• Date: Friday, September 26, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers' in-depth preview of Friday's Orioles vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Yankees, with a 57% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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