Orioles vs. Yankees Prediction: Yankees Predicted to Win Saturday's MLB Matchup [6/21/2025]

The New York Yankees will take on the Baltimore Orioles in MLB action at Yankee Stadium on Saturday, starting at 1:05PM ET.

Clarke Schmidt (3-3, 3.16 ERA) will start for the Yankees, while the Orioles are going with Zach Eflin (6-3, 4.81 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Yankees as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Orioles-Yankees game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Yankees are more likely to win, while the Orioles have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Orioles vs. Yankees predictions page.

Yankees vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Orioles and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 61% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 56% chance of covering the run line, while the over/under total of 9.5 runs has a 54% chance of staying under.

Orioles vs. Yankees Odds [6/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Yankees
Run Line	+1.5 (-139)	-1.5 (+120)
Moneyline	+147	-174
Total	o9.5 (+100)	u9.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Yankees Picks and Best Bets

Our model's biggest edge in today's Orioles vs. Yankees matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Orioles vs. Yankees Game-Day Updates and Essential Details

Saturday's MLB action between the Yankees and Orioles at Yankee Stadium is scheduled to commence at 1:05PM ET.

• Who: Baltimore Orioles vs. New York Yankees
• Date: Saturday, June 21, 2025
• Time: 1:05PM ET/10:05AM PT
• Venue: Yankee Stadium

Dimers.com's in-depth preview of Saturday's Orioles vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Yankees, with a 61% win probability, will likely beat the Orioles on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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