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Orioles vs. Brewers Prediction: Milwaukee Predicted to Win Wednesday's MLB Matchup [5/21/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Our expert prediction for Wednesday's Baltimore Orioles vs Milwaukee Brewers matchup.
The Milwaukee Brewers will face the Baltimore Orioles, in what is expected to be a close MLB game, at American Family Field on Wednesday, commencing at 1:10PM ET.
Chad Patrick (2-4, 3.35 ERA) will start on the mound for the Brewers, pitting him against Tomoyuki Sugano (4-3, 3.08 ERA) for the Orioles.
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Brewers as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Baltimore-Milwaukee game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Brewers' chance of winning at 51%, with the Orioles at 49%."
For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Orioles vs. Brewers predictions page.
Brewers vs. Orioles Prediction: Who Will Win?
Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Orioles and Brewers 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Brewers a 51% chance of defeating the Orioles.
According to our model, the over/under total of 8.5 runs has a 53% chance of staying under.
Orioles vs. Brewers Odds [5/21/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Orioles | Brewers |
|---|---|---|
| Moneyline | -105 | -108 |
| Total | o8.5 (-110) | u8.5 (-102) |
All odds are correct at the time of publication and are subject to change.
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Orioles vs. Brewers Picks and Best Bets
Our model's strongest edge in today's Orioles vs. Brewers matchup is on the moneyline.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets Today
Calling Our Shot produces daily MLB betting content, including the predictions featured below.
Orioles vs. Brewers Game-Day Updates and Essential Details
Wednesday's MLB matchup between the Brewers and Orioles at American Family Field is scheduled to commence at 1:10PM ET.
- Who: Baltimore Orioles vs. Milwaukee Brewers
- Date: Wednesday, May 21, 2025
- Time: 1:10PM ET/10:10AM PT
- Venue: American Family Field
Dimers.com's comprehensive preview of Wednesday's Orioles vs. Brewers matchup includes our prediction, picks and the latest betting odds.
Before making any Baltimore vs. Milwaukee picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Brewers, with a 51% win probability, will likely beat the Orioles on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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