Orioles vs. Guardians Prediction: Cleveland Predicted to Win Wednesday's MLB Matchup [7/23/2025]

The Cleveland Guardians and Baltimore Orioles are scheduled to meet in MLB action at Progressive Field on Wednesday, starting at 6:40PM ET.

Slade Cecconi (5-4, 3.84 ERA) will start for the Guardians, up against Zach Eflin (6-5, 5.95 ERA) for the Orioles.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Orioles-Guardians game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 53%, with the Orioles at 47%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Orioles vs. Guardians predictions page.

Guardians vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Orioles and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Guardians a 53% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 65% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Orioles vs. Guardians Odds [7/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Guardians
Run Line	+1.5 (-190)	-1.5 (+157)
Moneyline	+110	-130
Total	o8.5 (-115)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Orioles vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Orioles vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Guardians and Orioles at Progressive Field is scheduled to start at 6:40PM ET.

• Who: Baltimore Orioles vs. Cleveland Guardians
• Date: Wednesday, July 23, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Progressive Field

Dimers.com's full preview of Wednesday's Orioles vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 53% win probability, will likely beat the Orioles on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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