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Orioles vs. Guardians Prediction: Cleveland Predicted to Win Monday's MLB Matchup [7/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Monday's Baltimore Orioles vs Cleveland Guardians matchup.
The Cleveland Guardians and Baltimore Orioles will meet in MLB action at Progressive Field on Monday, starting at 6:40PM ET.
Tanner Bibee (5-9, 4.29 ERA) will start on the mound for the Guardians, while the Orioles have opted for Tomoyuki Sugano (7-5, 4.44 ERA).
Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.
For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Orioles vs. Guardians predictions page.
Guardians vs. Orioles Prediction: Who Will Win, Cover the Run Line?
Using innovative machine learning and data, we have simulated the result of Monday's MLB game between the Orioles and Guardians 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Guardians a 56% chance of defeating the Orioles.
According to our model, the Orioles (+1.5) have a 62% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.
Orioles vs. Guardians Odds [7/21/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Orioles | Guardians |
|---|---|---|
| Run Line | +1.5 (-175) | -1.5 (+148) |
| Moneyline | +120 | -135 |
| Total | o8.5 (-104) | u8.5 (-114) |
All odds are correct at the time of publication and are subject to change.
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Orioles vs. Guardians Picks and Best Bets
Our model's biggest edge in today's Orioles vs. Guardians matchup is on the moneyline.
Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.
Orioles vs. Guardians Game-Day Updates and Essential Details
Monday's MLB matchup between the Guardians and Orioles at Progressive Field is scheduled to begin at 6:40PM ET.
- Who: Baltimore Orioles vs. Cleveland Guardians
- Date: Monday, July 21, 2025
- Time: 6:40PM ET/3:40PM PT
- Venue: Progressive Field
Dimers.com's full preview of Monday's Orioles vs. Guardians matchup includes our prediction, picks and the latest betting odds.
Before making any Orioles vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Guardians, with a 56% win probability, will likely beat the Orioles on Monday.
AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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