Orioles vs. White Sox prediction: Why Baltimore is favored to win Wednesday's MLB matchup [9/17/2025]

The Chicago White Sox will take on the Baltimore Orioles, in what is expected to be a tight MLB game, at Rate Field on Wednesday, commencing at 2:10PM ET.

Martín Pérez (1-5, 3.27 ERA) will start for the White Sox, while the Orioles are going with Tyler Wells (1-0, 2.31 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Orioles as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Orioles-White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Orioles' chance of winning at 54%, with the White Sox at 46%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Orioles vs. White Sox predictions page.

White Sox vs. Orioles prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Orioles and White Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Orioles a 54% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Orioles vs. White Sox odds [9/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	White Sox
Run Line	-1.5 (+138)	+1.5 (-160)
Moneyline	-122	+110
Total	o8.5 (-102)	u8.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. White Sox picks and best bets

Our model's biggest edge in today's Orioles vs. White Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Orioles vs. White Sox game-day updates and essential details

Wednesday's MLB action between the White Sox and Orioles at Rate Field is scheduled to start at 2:10PM ET.

• Who: Baltimore Orioles vs. Chicago White Sox
• Date: Wednesday, September 17, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Rate Field

Dimers' in-depth preview of Wednesday's Orioles vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Orioles, with a 54% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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