Orioles vs. White Sox prediction: Why Baltimore is favored to win Tuesday's MLB matchup [9/16/2025]

The Chicago White Sox will square off with the Baltimore Orioles in MLB action at Rate Field on Tuesday, commencing at 7:40PM ET.

Shane Smith (6-7, 3.78 ERA) will start for the White Sox, pitting him against Dean Kremer (9-10, 4.43 ERA) for the Orioles.

Based on the latest simulations, Dimers' advanced MLB model projects the Orioles as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Orioles vs. White Sox predictions page.

White Sox vs. Orioles prediction: Who will win?

Using powerful machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Orioles and White Sox 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Orioles a 51% chance of beating the White Sox.

According to our model, the 8-run over/under has a 51% chance of going over.

Orioles vs. White Sox odds [9/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	White Sox
Moneyline	-106	-109
Total	o8 (-102)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. White Sox picks and best bets

Our model's strongest edge in today's Orioles vs. White Sox matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Orioles vs. White Sox game-day updates and essential details

Tuesday's MLB matchup between the White Sox and Orioles at Rate Field is scheduled to start at 7:40PM ET.

• Who: Baltimore Orioles vs. Chicago White Sox
• Date: Tuesday, September 16, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers' in-depth preview of Tuesday's Orioles vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 51% win probability, will likely beat the White Sox on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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