Orioles vs. White Sox prediction: Why Baltimore is favored to win Monday's MLB matchup [9/15/2025]

MLB action continues on Monday at 7:40PM ET as the Baltimore Orioles square off with the Chicago White Sox at Rate Field.

The White Sox will send Sean Burke (4-10, 4.35 ERA) to the mound, up against Kyle Bradish (0-1, 2.65 ERA) for the Orioles.

Based on updated simulations, Dimers' advanced MLB model projects the Orioles as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Orioles vs. White Sox predictions page.

White Sox vs. Orioles prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Orioles and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Orioles a 56% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 58% chance of covering the run line, while the 8-run over/under has a 51% chance of going over.

Orioles vs. White Sox odds [9/15/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	White Sox
Run Line	-1.5 (+118)	+1.5 (-135)
Moneyline	-142	+120
Total	o8 (-105)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. White Sox picks and best bets

Our model's strongest edge in today's Orioles vs. White Sox matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Orioles vs. White Sox game-day updates and essential details

Monday's MLB matchup between the White Sox and Orioles at Rate Field is scheduled to start at 7:40PM ET.

• Who: Baltimore Orioles vs. Chicago White Sox
• Date: Monday, September 15, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers' full preview of Monday's Orioles vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 56% win probability, will likely beat the White Sox on Monday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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