Orioles vs. Cubs Prediction: Cubs Predicted to Win Friday's MLB Matchup [8/1/2025]

MLB action continues on Friday at 2:20PM ET as the Baltimore Orioles lock horns with the Chicago Cubs at Wrigley Field.

Cade Horton (4-3, 3.67 ERA) will be the starting pitcher for the Cubs, pitting him against Trevor Rogers (4-1, 1.49 ERA) for the Orioles.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Orioles vs. Cubs predictions page.

Cubs vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Friday's MLB game between the Orioles and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Cubs a 59% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 60% chance of covering the run line, while the over/under total of 7 runs has a 53% chance of going over.

Orioles vs. Cubs Odds [8/1/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Cubs
Run Line	+1.5 (-178)	-1.5 (+150)
Moneyline	+126	-150
Total	o7 (-102)	u7 (-115)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Orioles vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Orioles vs. Cubs Game-Day Updates and Essential Details

Friday's MLB matchup between the Cubs and Orioles at Wrigley Field is scheduled to commence at 2:20PM ET.

• Who: Baltimore Orioles vs. Chicago Cubs
• Date: Friday, August 1, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Friday's Orioles vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Orioles vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 59% win probability, will likely beat the Orioles on Friday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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