Orioles vs. Red Sox Prediction: Boston Predicted to Win Thursday's MLB Matchup [5/22/2025]

The Boston Red Sox will square off with the Baltimore Orioles, in what is expected to be a tight MLB game, at Fenway Park on Thursday, commencing at 6:45PM ET.

Lucas Giolito (1-1, 7.08 ERA) will start for the Red Sox, while the Orioles are going with Cade Povich (1-3, 5.23 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Red Sox as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Baltimore-Boston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Red Sox with a win probability of 52% and the Orioles with 48%."

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Orioles vs. Red Sox predictions page.

Red Sox vs. Orioles Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Thursday's MLB game between the Orioles and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Red Sox a 52% chance of beating the Orioles.

According to our model, the Orioles (+1.5) have a 66% chance of covering the run line, while the 8-run over/under has a 52% chance of going over.

Orioles vs. Red Sox Odds [5/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Orioles	Red Sox
Run Line	+1.5 (-192)	-1.5 (+165)
Moneyline	+110	-126
Total	o8 (-118)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Orioles vs. Red Sox Picks and Best Bets

Our model's strongest edge in today's Orioles vs. Red Sox matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Orioles vs. Red Sox Game-Day Updates and Essential Details

Thursday's MLB action between the Red Sox and Orioles at Fenway Park is scheduled to begin at 6:45PM ET.

• Who: Baltimore Orioles vs. Boston Red Sox
• Date: Thursday, May 22, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Fenway Park

Dimers.com's full preview of Thursday's Orioles vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Baltimore vs. Boston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Red Sox, with a 52% win probability, will likely beat the Orioles on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Orioles vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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