Arizona vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 5, 2025

Iowa State will take on Arizona in Week 5 college football action at Jack Trice Stadium on Saturday, starting at 7:00PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Iowa State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Arizona vs. Iowa State predictions page.

Arizona vs. Iowa State prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Arizona vs. Iowa State 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Iowa State a 62% chance of beating Arizona. Our predicted final score has Iowa State winning 26-22.

According to our model, Arizona (+5.5) has a 52% chance of covering the spread, while the over/under total of 48.5 points has an equal 50-50 chance of hitting.

Arizona vs. Iowa State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Arizona	Iowa State
Spread	+5.5 (-110)	-5.5 (-105)
Moneyline	+180	-210
Total	o48.5 (-110)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Arizona vs. Iowa State picks and best bets

Our model's strongest edge in today's Arizona vs. Iowa State matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Arizona vs. Iowa State game-day updates and essential details

Saturday's college football game between Iowa State and Arizona at Jack Trice Stadium is scheduled to start at 7:00PM ET.

• Who: Arizona vs. Iowa State
• Date: Saturday, September 27, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Jack Trice Stadium

Dimers' comprehensive preview of Saturday's Arizona vs. Iowa State matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. Iowa State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict Iowa State, with a 62% win probability, will likely beat Arizona on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Arizona vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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